The main interest of our group is the identification of mechanisms of cancer prevention by food and food constituents. The established techniques are focused on the analysis of signal transduction and gene and protein transcription. In the first period of the project, we could show that a polyphenol-rich extract of a consumer-relevant apple juice blend was found to potently inhibit the growth of human colon cancer cells enhance apoptosis (programmed cell death) and affect proliferation-associated signaling cascades.
The characterisation of active constituents and the identification of potential biomarkers of chemoprevention in the colon are under current investigation.
Period: 1.7.2005 – 31.6.2009
Contact
Prof. Dr. Doris Marko
Universität Karlsruhe
Institut für Angewandte Biowissenschaften
Abteilung für Lebensmittelchemie und Toxikologie
Fritz-Haber-Weg 2
76131 Karlsruhe
Phone +49(0)721 608-2936
Fax +49(0)721 608-7255
doris.marko@lmc.uni-karlsruhe.de
1.3 Uni Karlsruhe
Industrial Partner VK Mühlen AG